In a maximum of 3 pages, please summarize the following points:
Background of the discovery/invention
Advantages and disadvantages of the technology
Required steps to move the technology into the clinic³
Intellectual Property position¹
Patent status
Relevant related patents, if any
Prior art and freedom to operate
Market – size, potential, barriers which may be encountered
What is the opportunity?
Impact on public health², regional, national or global health priorities, and the Canadian economy
¹All technologies should be patented (filed or issued).
²The technology must address a public health problem/issue.
³The technology must be past the proof-of-concept stage with animal models.
The three influenza viruses that affect humans are Influenzavirus A (humans, other mammals & birds), Influenzavirus B (humans & seals), and Influenzavirus C (humans & pigs). Influenzavirus A is responsible for most flu pandemics. The virus can be transmitted through airborne particles – coughs or sneezes – contaminated surfaces, or in the case of avian influenza, through infected bird droppings. The influenza virus can survive in sub-zero temperatures, but is easily killed with disinfectants and detergents.
Inoculation (also known as variolation) was introduced to the west by Lady Mary Wortley Montagu (1689-1762), who witnessed inoculation being
practiced by physicians in Constantinople,[12] and was greatly impressed:[13] she had lost a brother to smallpox and bore facial scars from the disease herself. In 1718 she had the embassy surgeon inoculate her son, and in 1721, after returning to England, had her daughter inoculated[14]. In 1722 the Prince of Wales' daughters received inoculations[16].
The practice of inoculation slowly spread amongst the royal families of Europe, followed by general adoption amongst the rest of the population. Given the severe consequences of smallpox in Europe in the 18th century, many parents felt that the benefits outweighed the risks and so inoculated their children.[21] [22]
