PREVENT partners

Research | Patents, Facilities & Training

VIDO/InterVac

Saskatoon: The Vaccine and Infectious Disease Organization (VIDO), a non-profit organization owned by the University of Saskatchewan, is a world leader in the research and development of vaccines and immunity-enhancing technologies for humans and animals. It brings preclinical research capacity (Containment Level 2 laboratory and animal facilities) and is leading development of the International Vaccine Centre (InterVac), Canada's largest Containment Level 3 laboratory dedicated to vaccine development and capable of testing vaccines for large animals.

VIDO's work to develop cost-effective and easily administered vaccines is critical for rapid response against existing and emerging infectious disease threats. VIDO's research efforts strengthen the competitiveness of the livestock industry and protect the health of Canadians.

Research

VIDO's research activities continue to address infectious diseases of importance to the human and animal health industries. As new diseases emerge, the development of control and prevention strategies becomes more important than ever. Many of VIDO's research programs, therefore, are committed to developing better understanding of disease threats such as avian flu, prion diseases and West Nile virus and the development of technologies that will facilitate rapid and cost-effective delivery of vaccines in the event of disease outbreaks.

Construction of the new International Vaccine Centre (InterVac) is underway and when completed this state-of-the-art facility will be the largest Bio-safety Containment Level 3 vaccine research centre in Canada devoted to vaccinology. This, along with VIDO's highly qualified team of research scientists, will enhance Canada's ability to conduct research into both human and large animal diseases.

Research efforts are concentrated on developing platform technologies that improve vaccine formulation and delivery for multiple diseases, species and vaccines, e.g. the focus is on the identification of novel adjuvants and immunomodulators as well as strategies for systemic and mucosal vaccine delivery. Disease targets include animal diseases such as chronic wasting disease, Johne's disease, and bovine mastitis as well as human diseases including RSV, pertussis, hepatitis C and influenza.

Recent food-borne diseases have caused significant economic and social impacts for both the livestock industry and the Canadian health care system. Many food-borne diseases have their origin in contaminated water and animal products. VIDO's food safety program is focused on developing intervention strategies for important pathogens such as E. coli 0157:H7, Campylobacter jejuni and Salmonella species and indeed has been involved in the development of a world's first vaccine for E.coli O157 in cattle.



Did you know?
image of BSE

A group of brain diseases, including BSE (or mad cow disease) and Creutzfeldt-Jacob disease of humans, are transmitted by "prions," which are infectious protein particles similar to a virus. BSE is carried by animal feed made from cattle brains or spinal cord, and ingestion of meat infected with the disease can cause CJD in humans. The brain of BSE-affected cows has a sponge-like appearance when tissue sections are examined in the lab.

Credit: Dr. Al Jenny.

Source: Public Health Image Library, APHIS, U.S. Department of Agriculture.

BACKGROUNDER

Immunization:
Inoculation and Vaccination

Inoculation (also known as variolation) was introduced to the west by Lady Mary Wortley Montagu (1689-1762), who witnessed inoculation being
portrait of lady
practiced by physicians in Constantinople,[12] and was greatly impressed:[13] she had lost a brother to smallpox and bore facial scars from the disease herself. In 1718 she had the embassy surgeon inoculate her son, and in 1721, after returning to England, had her daughter inoculated[14]. In 1722 the Prince of Wales' daughters received inoculations[16].

The practice of inoculation slowly spread amongst the royal families of Europe, followed by general adoption amongst the rest of the population. Given the severe consequences of smallpox in Europe in the 18th century, many parents felt that the benefits outweighed the risks and so inoculated their children.[21] [22]