PREVENT partners

Research | Facilities

The Canadian Center for Vaccinology

Facilities

The Canadian Center for Vaccinology is a 30,000 square foot vaccine research centre for basic translational science, epidemiology and clinical trials (Phases I-III), and implementation and evaluative policy research.

The Center's facilities include laboratories for microbiological and molecular research, ambulatory clinical trial facilities, and data analysis, training, and videoconferencing / telemedicine capabilities and a Containment Level 3 laboratory and a human vaccine challenge unit.

lab researcherThe "sanofi pasteur human vaccine challenge unit," a 5,400 sq. ft., ten-bed inpatient unit with isolation rooms, will be the first of its kind in Canada and, with less than a dozen such facilities worldwide, at the cutting edge of global vaccine research.

The Canadian Center for Vaccinology serves as an "academic pipeline" for Canadian vaccine priorities identified through the National Immunization Strategy. It facilitates public health policy development by enabling policy makers and planners to obtain scientific data upon which to base their decisions and evaluate the outcomes of implemented policies. As one of the three partner institutions in the recently formed Pan-Provincial Vaccine Enterprise (PREVENT), the CCfV will play an integral role in accelerating promising Canadian vaccine discoveries through preclinical and early clinical evaluation and catalyzing the commercialization of viable products that meet Canada's public health priorities.

The CCfV in Halifax, together with other vaccine centres elsewhere in Canada such as in British Columbia (Vaccine Evaluation Center and the BC Centre for Disease Control, Vancouver), Saskatchewan (Vaccine and Infectious Disease Organization, Saskatoon), and Quebec (McGill University, Montreal, and Institut national de santé publique du Québec, Quebec City), form a nationwide network for collaborative and complementary vaccine research.



Did you know?
image of BSE

A group of brain diseases, including BSE (or mad cow disease) and Creutzfeldt-Jacob disease of humans, are transmitted by "prions," which are infectious protein particles similar to a virus. BSE is carried by animal feed made from cattle brains or spinal cord, and ingestion of meat infected with the disease can cause CJD in humans. The brain of BSE-affected cows has a sponge-like appearance when tissue sections are examined in the lab.

Credit: Dr. Al Jenny.

Source: Public Health Image Library, APHIS, U.S. Department of Agriculture.

BACKGROUNDER

Immunization:
Inoculation and Vaccination

Inoculation (also known as variolation) was introduced to the west by Lady Mary Wortley Montagu (1689-1762), who witnessed inoculation being
portrait of lady
practiced by physicians in Constantinople,[12] and was greatly impressed:[13] she had lost a brother to smallpox and bore facial scars from the disease herself. In 1718 she had the embassy surgeon inoculate her son, and in 1721, after returning to England, had her daughter inoculated[14]. In 1722 the Prince of Wales' daughters received inoculations[16].

The practice of inoculation slowly spread amongst the royal families of Europe, followed by general adoption amongst the rest of the population. Given the severe consequences of smallpox in Europe in the 18th century, many parents felt that the benefits outweighed the risks and so inoculated their children.[21] [22]